Analysis of Low-Density Lipoprotein Cholesterol by Homogenous Assay in Comparison with Friedewald Formula / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 104-108, 2003.
Artigo
em Coreano
| WPRIM
| ID: wpr-32431
ABSTRACT
BACKGROUND:
Low-density lipoprotein cholesterol (LDL-C) is a major risk factor in atherogenesis and coronary heart disease as well as a primary target of lipid-lowering therapy. LDL-C concentration by direct homogenous assay was compared with that of the Friedewald formula, which is widely used in spite of its limitations.METHODS:
Between February and March 2002, we analyzed total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and LDL-C levels in 1, 161 subjects (601 men and 560 women). They were classified according to cutpoints of the National Cholesterol Education Program Adult Treatment Panel III guidelines. The LDL-C results by direct method and the Friedewald formula were compared according to the TG levels and their medical decision values.RESULTS:
Overall results of the direct method (Y) and the Friedewald formula (X) were highly correlated (Y=0.90X+13.62, r=0.9225). LDL-C by the Friedewald formula, however, showed a tendency of underestimation at higher TG levels. The results of the direct method were significantly different compared with those of the Friedewald formula when TG > or =200 mg/dL (P or =200 mg/dL. Therefore, a direct determination method with better analytical performance is required. A fully automated homogenous assay seems to improve the determination of LDL-C, and may have a role in the diagnosis and management of hyperlipidemic patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Triglicerídeos
/
Colesterol
/
Fatores de Risco
/
Doença das Coronárias
/
Diagnóstico
/
Educação
/
Aterosclerose
/
Lipoproteínas
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Guia de Prática Clínica
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
The Korean Journal of Laboratory Medicine
Ano de publicação:
2003
Tipo de documento:
Artigo
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