Studies on chemical constituents of Laurencia tristicha ( II ) / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2610-2612, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-324321
ABSTRACT
<p><b>OBJECTIVE</b>To search for chemical constituents with structural diversity from Laurencia tristicha to supply for biological assay.</p><p><b>METHOD</b>Compounds were isolated by means of column chromatography over normal phase silica gel and Sephadex LH-20, recrystallization and HPLC. Structures were identified by spectroscopic methods including 1D NMR, IR and MS. Cytotoxicities of the purified compounds were evaluated by MTT method.</p><p><b>RESULT</b>Seven compounds were isolated from L. tristicha. Their structures were elucidated as cholesterol (1), cholesta- 5-en-3beta, 7alpha-diol (2), beta-stigmasterol (3), phytol (4), zeaxanthin (5), 4 -hydroxybenzaldehyde (6), indolyl-3-carbaldehyde (7). In the cytotoxic assay compound 2 was active against human cancer cell lines HCT-8, Bel-7402, BGc-823, A549 and HELA with IC50 values of 1.90, 2.02, 1.99, 6.52 and 1.20 microg x mL(-1), respectively. Compound 4 showed cytotoxicity against HCT-8 and HELA with IC50 value of 3.51 and 2.04 microg x mL(-1), and other compounds were inactive ( IC50 > 10 microg x mL(-1)).</p><p><b>CONCLUSION</b>Compounds 1-7 were isolated from L. tristicha for the first time. In additon, compounds 2 and 4 were cytotoxic against several human cancer cell lines.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fitol
/
Química
/
Colestenos
/
Colesterol
/
Concentração Inibidora 50
/
Linhagem Celular Tumoral
/
Laurencia
/
Antineoplásicos
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Artigo
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