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Studies on chemical constituents of Laurencia tristicha ( II ) / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2610-2612, 2007.
Artigo em Chinês | WPRIM | ID: wpr-324321
ABSTRACT
<p><b>OBJECTIVE</b>To search for chemical constituents with structural diversity from Laurencia tristicha to supply for biological assay.</p><p><b>METHOD</b>Compounds were isolated by means of column chromatography over normal phase silica gel and Sephadex LH-20, recrystallization and HPLC. Structures were identified by spectroscopic methods including 1D NMR, IR and MS. Cytotoxicities of the purified compounds were evaluated by MTT method.</p><p><b>RESULT</b>Seven compounds were isolated from L. tristicha. Their structures were elucidated as cholesterol (1), cholesta- 5-en-3beta, 7alpha-diol (2), beta-stigmasterol (3), phytol (4), zeaxanthin (5), 4 -hydroxybenzaldehyde (6), indolyl-3-carbaldehyde (7). In the cytotoxic assay compound 2 was active against human cancer cell lines HCT-8, Bel-7402, BGc-823, A549 and HELA with IC50 values of 1.90, 2.02, 1.99, 6.52 and 1.20 microg x mL(-1), respectively. Compound 4 showed cytotoxicity against HCT-8 and HELA with IC50 value of 3.51 and 2.04 microg x mL(-1), and other compounds were inactive ( IC50 > 10 microg x mL(-1)).</p><p><b>CONCLUSION</b>Compounds 1-7 were isolated from L. tristicha for the first time. In additon, compounds 2 and 4 were cytotoxic against several human cancer cell lines.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Fitol / Química / Colestenos / Colesterol / Concentração Inibidora 50 / Linhagem Celular Tumoral / Laurencia / Antineoplásicos Limite: Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Fitol / Química / Colestenos / Colesterol / Concentração Inibidora 50 / Linhagem Celular Tumoral / Laurencia / Antineoplásicos Limite: Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2007 Tipo de documento: Artigo