Beta-carotene protects rats against bronchitis induced by cigarette smoking / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 514-516, 2003.
Article
em En
| WPRIM
| ID: wpr-324400
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effects of beta-carotene in rats against the development of chronic bronchitis induced by cigarette smoking.</p><p><b>METHODS</b>Forty-two Male Wistar rats were randomly divided into three study groups: (1) control (n = 15), animals underwent no treatment; (2) cigarette smoking (n = 15), animals developed chronic bronchitis through long-term cigarette smoking twice a day for 75 d; (3) beta-carotene plus cigarette smoking animals (n = 12) were given 1 ml or 15 mg/kg beta-carotene orally every day just before cigarette smoking. The levels of IL-6, IL-8, NO, superoxide dismutase (SOD) and lipoperoxide (LPO) in serum, bronchoalveolar lavage fluid (BALF) and lung tissue were measured and the pathological changes to lung tissue were analyzed using light microscopy.</p><p><b>RESULTS</b>Long-term cigarette smoking caused an obvious increase in the amount of IL-6, IL-8 and LPO and a sharp decrease in the levels of NO and SOD in smoking animals compared to controls. beta-carotene intake reversed all the changes induced by smoking and alleviated the pathological changes caused by chronic bronchitis.</p><p><b>CONCLUSIONS</b>Quantitative oral intake of beta-carotene had protective effects against chronic bronchitis induced by long-term cigarette smoking, which was associated with the increased production of NO, the clearance of some oxidative free radicals (OFR) and the alleviation of chronic inflammation.</p>
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WPRIM
Assunto principal:
Farmacologia
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Superóxido Dismutase
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Sangue
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Bronquite
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Fumar
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Interleucina-8
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Interleucina-6
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Ratos Wistar
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Beta Caroteno
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Óxido Nítrico
Limite:
Animals
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2003
Tipo de documento:
Article