Molecular recognition code between pathogenic bacterial TAL-effectors and host target genes: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1132-1141, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-324479
ABSTRACT
As the pathogenic bacterial virulence and avirulence factors, transcription activator like (TAL) effectors of Xanthomonas can resulted in the host diseases or resistance responses. TAL effectors can specifically bind the target DNA of host plant with a novel protein-DNA binding pattern in which two amino acids recognize one nucleotide. The complexities of TAL-DNA binding have the feasibility in use of gene therapy through homologous recombination and site-specific mutation. By using the molecular recognition code between TAL-effectors and host target genes, we can exploit both the susceptible and resistance genes; broad spectrum resistance induced by multiple TAL effectors could also be manipulated. Deeper insight in the area of protein-DNA binding mechanism will benefit the application in the biomedical engineering and agricultural engineering. This article reviews the findings and functions of TAL effectors, the binding specificity and recognition code between TAL-effectors and host target genes. The possible applications and future prospects of the molecular recognition code have been discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças das Plantas
/
Virulência
/
Xanthomonas
/
Dados de Sequência Molecular
/
Sequência de Bases
/
Ativação Transcricional
/
Genes de Plantas
/
DNA de Plantas
/
Fatores de Virulência
/
Interações Hospedeiro-Patógeno
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2011
Tipo de documento:
Artigo
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