Overview of Gp96 mediated immunity / 生物工程学报
Chinese Journal of Biotechnology
; (12): 704-711, 2011.
Article
em Zh
| WPRIM
| ID: wpr-324547
Biblioteca responsável:
WPRO
ABSTRACT
As a member of the HSP90 family, heat shock protein (HSP) Gp96 is one of the most abundant proteins in the endoplasmic reticulum (ER), which displayed important molecular chaperones function in cells. Gp96 can stimulate the production of cytokines by activating the antigen presentation cells (such as dendritic cell, et al) in innate immunity. It is capable of eliciting an antigen-specific cytotoxic T lymphocyte (CTL) immune response to eliminate pathogens and tumors by facilitating antigen cross-presentation in adaptive immunity. Gp96 is also an ideal adjuvant in many recent researches. Here, we review the progress that addresses the role of biological characteristics, immunogenic mechanism that may be involved in the induction of anti-infection immune response and antitumor immunity, which may guide the new vaccine strategies with the knowledge of Gp96-antigen complexes.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fisiologia
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Células Dendríticas
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Glicoproteínas de Membrana
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Linfócitos T Citotóxicos
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Adjuvantes Imunológicos
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Doenças Transmissíveis
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Retículo Endoplasmático
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Alergia e Imunologia
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Genética
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Metabolismo
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2011
Tipo de documento:
Article