An experimental study on pulmonary toxicity water extracts of Siegesbeckia pubescens on mice / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2820-2822, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-324796
ABSTRACT
<p><b>OBJECTIVE</b>The pulmonary toxicity of water extract of Siegesbeckia pubescens has been studied an mice following subchronic oral administration route.</p><p><b>METHOD</b>Mice were randomly grouped and administered with the water extract of S. pubescens at dosages of 3.0, 1.0, 0.3 g x kg(-1) and saline respectively. 10 mice of each group were sacrificed on the day of 7 th, 14 th, 21 th, and 2 weeks after stopping administration, histological changes of the lung were examined.</p><p><b>RESULT</b>The water extract of S. pubescens at dosage of 3.0 g x kg(-1) increased the lung index on the of day 14 th and 21 th, significant histopathological damages were observed. The histopathological changes were disappeared after stopping administration for 2 weeks.</p><p><b>CONCLUSION</b>The water extract of S. pubescens has a pulmonary toxic effect on mice, and the toxic effect is reversible.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medicamentos de Ervas Chinesas
/
Distribuição Aleatória
/
Química
/
Administração Oral
/
Asteraceae
/
Toxicidade
/
Pulmão
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Artigo
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