A new statistical method on familial correlation dealing with family data from case-control studies / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>This paper presents a statistical method of familial correlation on family data from case-control studies.</p><p><b>METHODS</b>Marginal mean models of the probands and the relatives conditional on the proband's disease status, as well as the marginal association model of the relatives were modeled integrately. Conditional odds-ratio and marginal odds-ratio were used to measure the familial correlation.</p><p><b>RESULTS</b>The parameter's interpretation in the model was in accordance with sample characteristics. This method is more efficient due to making fully use of information of the probands and relatives. In addition, the method has all advantages of GEE2.</p><p><b>CONCLUSION</b>The method in this paper efficiently and conveniently analyzes the family data from case-control studies to estimate the familial correlation on disease.</p>