Influences of environmental factors and interaction of several chemokines gene-environmental on systemic lupus erythematosus / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the impact of environmental factors, daily lifestyle, psycho-social factors and the interactions between environmental factors and chemokines genes on systemic lupus erythematosus (SLE).</p><p><b>METHODS</b>Case-control study was carried out and environmental factors for SLE were analyzed by univariate and multivariate unconditional logistic regression. Interactions between environmental factors and chemokines polymorphism contributing to systemic lupus erythematosus were also analyzed by logistic regression model.</p><p><b>RESULTS</b>There were nineteen factors associated with SLE when univariate unconditional logistic regression was used. However, when multivariate unconditional logistic regression was used, only five factors showed having impacts on the disease, in which drinking well water (OR=0.099) was protective factor for SLE, and multiple drug allergy (OR=8.174), over-exposure to sunshine (OR=18.339), taking antibiotics (OR=9.630) and oral contraceptives were risk factors for SLE. When unconditional logistic regression model was used, results showed that there was interaction between eating irritable food and -2518MCP-1G/G genotype (OR=4.387). No interaction between environmental factors was found that contributing to SLE in this study.</p><p><b>CONCLUSION</b>Many environmental factors were related to SLE, and there was an interaction between -2518MCP-1G/G genotype and eating irritable food.</p>