Dynamic changes of serum MCP-1 and MIP-2 chemokines after renal transplantation in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2512-2516, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-325075
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes in serum levels of chemokine MCP-1 and MIP-2 after renal transplantation in rats and the influence of Cyclosporin A (CsA) on their levels.</p><p><b>METHODS</b>Three groups of rats, namely untreated group, CsA group and isograft group underwent the renal transplantation, and the serum MCP-1 and MIP-2 levels of the recipients were tested using enzyme-linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>The serum MCP-1 level peaked 6 hours after the operation and also in critical stages of acute rejection. The first peak of MCP-1 was postponed by the application of CsA, which did not affect the peak level (P>0.05). The second peak of MCP-1 did not occur in CsA-treated group. MIP-2 concentration also peaked at 6 h after the operation in all the groups. The second peak of MIP-2, which was lower than the first one (P<0.05), occurred 9 days after the transplantation.</p><p><b>CONCLUSION</b>MCP-1 and MIP-2 in involved not only in the ischemia-reperfusion injury but also in severe acute rejection. CsA has no significant effect on serum levels of MCP-1 and MIP-2 following renal transplantation in rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Período Pós-Operatório
/
Sangue
/
Traumatismo por Reperfusão
/
Transplante de Rim
/
Ciclosporina
/
Ratos Wistar
/
Ratos Sprague-Dawley
/
Quimiocina CCL2
/
Tratamento Farmacológico
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Artigo
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