Analysis of the risk factors of pulmonary fungal infections related to hematologic malignancies / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the risk factors of pulmonary fungal infections related to hematologic malignancies.</p><p><b>METHODS</b>A retrospective case-controlled study was conducted to analyze the patients with pulmonary fungal and bacterial infections in association with hematologic malignancies. The risk factors of pulmonary fungal infections related to hematologic malignancies were identified.</p><p><b>RESULTS</b>Three hundred and four cases (194 of pulmonary fungal infections and 110 of pulmonary bacterial infections) were enrolled in this study. Univariate analysis and multivariate logistic regression show that such factors as corticosteroid, halo sign, previous fungal infections, ANC lower than 0.5 x 10(9)/L for over 10 days, nodus near pleura, transplantation (immunodepressant use), chemotherapy, and broad spectrum antibiotics were all the independent risk factors of pulmonary fungal infections related to hematologic malignancies.</p><p><b>CONCLUSION</b>There are many risk factors for pulmonary fungal infections related to hematologic malignancies, and early identification of these factors for timely antifungal treatment is of much clinical significance.</p>