Clinical significance of tumor interstitial T lymphocyte subset activity in non-small-cell lung cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2456-2458, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-325091
ABSTRACT
<p><b>OBJECTIVE</b>To study the relation of tumor interstitial T lymphocyte subset activity to the clinical staging of non-small-cell lung cancer (NSCLC) and the immune response.</p><p><b>METHODS</b>Immunohistochemical staining for CD4(+), CD8(+) and CD4(+)CD25(+) Foxp3(+) (regulatory T cells, Treg) T cells was performed on paraffin-embedded tissues from 60 NSCLC cases.</p><p><b>RESULTS</b>Compared to stage I/II NSCLC patients, patients in stage III/IV showed a significant decrease in the percentage of CD4(+) and CD4(+)/CD8(+) T cells (P<0.05) and an increase in CD8(+) and CD4(+)CD25(+) Foxp3(+) T cells (P<0.05). Treg cells were enriched in the tumor tissue as compared with those in the adjacent tissues.</p><p><b>CONCLUSIONS</b>The proportion of CD4(+)CD25(+) Foxp3(+) Treg cells is positively correlated to the clinical staging of NSCLC, in which T cell-mediated immune response is suppressed.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Subpopulações de Linfócitos T
/
Linfócitos T Reguladores
/
Carcinoma Pulmonar de Células não Pequenas
/
Alergia e Imunologia
/
Pulmão
/
Neoplasias Pulmonares
/
Estadiamento de Neoplasias
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Artigo
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