Absorption characteristics of ginsenoside Rb2 in Caco-2 cell monolayer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2387-2390, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-325110
ABSTRACT
<p><b>OBJECTIVE</b>To determine the concentration of ginsenoside Rb(2) and study the absorption characteristics of ginsenoside Rb(2) in Caco-2 cell monolayer.</p><p><b>METHODS</b>LC-MS-MS was used to determine the concentration of ginsenoside Rb(2), and the apparent permeability coefficient (P(app)) of ginsenoside Rb(2) was calculated.</p><p><b>RESULTS</b>P(app(AP-BL)) was 3.27 x 10(-7) cm.s(-1), P(app(BL-AP)) was 3.16 x 10(-6) cm.s(-1), and the efflux ratio (P(app(BL-AP))/P(app(AP-BL))) was 9.63.</p><p><b>CONCLUSION</b>The absorption characteristics of ginsenoside Rb(2) in Caco-2 cell model have been demonstrated.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacocinética
/
Células CACO-2
/
Ginsenosídeos
/
Absorção Intestinal
/
Cromatografia Gasosa-Espectrometria de Massas
/
Métodos
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Artigo
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