Changes of peripheral blood estradiol and testosterone in early stage after trauma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2262-2265, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-325130
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation of serum estradiol, testosterone and their ratio to the injury severity score (ISS) and Glasgow coma score (GCS) in patients with multiple traumatic injuries.</p><p><b>METHODS</b>The serum levels of estradiol and testosterone were determined by radioimmunoassay double antibody precipitation method in 95 patients with multiple traumatic injuries within 24 h after trauma. The patients were grouped according to the ISS or GCS (in cases with craniocerebral injury) for comparison of the serum estradiol and testosterone levels with those in 15 normal individuals.</p><p><b>RESULTS</b>In the acute stage of multiple trauma, a distinct declination of testosterone and a marked increment of estradiol were observed, and the changes were closely related to the severity of the trauma .The serum levels of estradiol and testosterone and their ratio differed significantly between patients with severe trauma (ISS>25) and the other groups (P<0.01), and also between patients with craniocerebral injury (with GCS of 3-5 or 5-8) and the other groups (P<0.01).</p><p><b>CONCLUSION</b>Serum estradiol and testosterone levels and their ratio are correlated to the severity of trauma and craniocerebral injuries, and may serve as indicators for evaluating the trauma severity and prognosis of the traumatic patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Testosterona
/
Fatores de Tempo
/
Sangue
/
Lesões Encefálicas
/
Radioimunoensaio
/
Traumatismo Múltiplo
/
Biomarcadores
/
Escala de Coma de Glasgow
/
Escala de Gravidade do Ferimento
/
Estradiol
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Artigo
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