Research progress on mechanism of bone marrow relapse in pediatric acute lymphoblastic leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 231-235, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-325178
ABSTRACT
The mechanism of bone marrow relapse in pediatric acute lymphoblastic leukemia has been deeply researched in recent years. The roles of hematopoietic stem cells, some gene abnormalities including IKZF1, JAK, CRLF2 and CREBBP, as well as mutation of genes influencing drug resistance have been confirmed to related with relapse of disease. The microRNAs, gene expression profile of patient, microenvironment of bone marrow including bone marrow fibrosis, mesenchymal stem cells and matrix metalloprotease, also play an important role in the process of leukemia recurrence. This article reviewed the details mentioned above.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Recidiva
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Limite:
Criança
/
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2013
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS