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Research progress of mesenchymal stem cell-derived microvesicle / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 227-230, 2013.
Artigo em Chinês | WPRIM | ID: wpr-325179
ABSTRACT
Mesenchymal stem cell-derived microvesicle (MSC-MV) is a membrane secretory system which includes microparticle and exosome, and MSC-MV is released by MSC in resting or activated state. MSC-MV selectively package the biological active substances such as lipids, proteins, mRNA and miRNA but not loads them randomly. It has definitive effect of reducing tissue injury, promoting morphological and functional recovery of the injured tissue, and this effect is probably mediated by miRNA. What is more, the MSC-MV may also possess the biological function of immunological regulation, modulation of cell growth and differentiation. The generation, constitution, and function of MSC-MV are reviewed in this article.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: MicroRNAs / Micropartículas Derivadas de Células / Células-Tronco Mesenquimais / Metabolismo Limite: Animais / Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: MicroRNAs / Micropartículas Derivadas de Células / Células-Tronco Mesenquimais / Metabolismo Limite: Animais / Humanos Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2013 Tipo de documento: Artigo