Your browser doesn't support javascript.
loading
Impact of hepatitis B virus infection on liver function after hematopoietic stem cell transplantation / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 173-176, 2013.
Artigo em Chinês | WPRIM | ID: wpr-325190
ABSTRACT
To analyze the impact of hepatitis B virus (HBV) infection on liver function of patients after hematopoietic stem cell transplantation (HSCT), the transplantation outcome of 48 patients infected with HBV prior to transplantation among 185 patients received HSCT was investigated retrospectively. The results showed that during a follow-up for 6 months after HSCT, the alanine aminotransferase (ALT) peak average values of the patients with HBsAg(+), HBsAb(+) and control groups were (281.6 ± 414.6), (95.4 ± 79.9) and (65.1 ± 44.2) U/L, respectively. The incidences of abnormal liver function of the patients with HBsAg(+), HBsAb(+) and control groups were 61.54%, 40.00% and 30.23% respectively. There were no significant differences between any two groups (P > 0.05). The lethality of those patients at late period after transplantation was not related to HBV infection. The hepatocirrhosis and hepatocarcinoma caused by HBV infection have not become major problems in long-term survivors. It is concluded that in HBsAg(+) patients received HSCT, the damage of liver function is more severe than control group, possibly increasing the development of abnormal liver function. The measures against the liver function damage should be taken. The prophylactic administration of ganciclovir for virus may be effective to prevent the activation of HBV.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Virologia / Hepatopatia Veno-Oclusiva / Vírus da Hepatite B / Estudos Retrospectivos / Transplante de Células-Tronco Hematopoéticas / Hepatite B / Fígado / Testes de Função Hepática Tipo de estudo: Estudo observacional Limite: Adolescente / Adulto / Criança / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2013 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Virologia / Hepatopatia Veno-Oclusiva / Vírus da Hepatite B / Estudos Retrospectivos / Transplante de Células-Tronco Hematopoéticas / Hepatite B / Fígado / Testes de Função Hepática Tipo de estudo: Estudo observacional Limite: Adolescente / Adulto / Criança / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Experimental Hematology Ano de publicação: 2013 Tipo de documento: Artigo