The approaches for making acute-on-chronic liver failure in rat / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 394-396, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-325531
ABSTRACT
<p><b>OBJECTIVE</b>To study the approaches for making acute-on-chronic hepatic failure model in rat.</p><p><b>METHODS</b>SD rats were intraperitoneally injected with 50% CCl4 (Carbon tetrachloride) olive solution every three days for 6 or 10 weeks. Then they were divided into two groups randomly and injected with D-galactosamine (D-gal) at a dose of 2 g/kg, lipopolysaccharide (LPS) at a dose of 100 pg/kg and D-gal at a dose of 0.5 g/kg BW respectively. The levels of serum ALT, AST and TBil were detected,and histopathological changes were observed to evaluate these two models.</p><p><b>RESULTS</b>After injection of 50% CCl4 olive solution intraperitoneally for 6 weeks, liver fibrosis happened in SD rats, 10 weeks, cirrhosis happened. Pelleta necrosis and massive or submassive necrosis was seen administration of two reagents mentioned above.</p><p><b>CONCLUSION</b>By injecting of 50% CCl4 olive solution intraperitoneally, acute-on-chronic liver failure model could be induced by D-gal, LPS/D-gal in rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Tetracloreto de Carbono
/
Distribuição Aleatória
/
Lipopolissacarídeos
/
Mortalidade
/
Ratos Sprague-Dawley
/
Falência Hepática Aguda
/
Alanina Transaminase
/
Modelos Animais de Doenças
/
Galactosamina
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2009
Tipo de documento:
Artigo
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