Study on the association between severe chronic hepatitis B and HLA-DRB1 gene polymorphism / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the association between HLA-DRB1 gene polymorphism and severe chronic hepatitis B.</p><p><b>METHODS</b>26 patients with severe chronic hepatitis B were investigated for HLA-DRB1 gene polymorphism by polymerase chain reaction-sequence specific primers technique. The results were compared with those from 45 normal healthy people by use of chi2-test of Microsoft SPSS 13.0.</p><p><b>RESULTS</b>The frequency of HLA-DRB1 * 1301/1302 allele in severe chronic hepatitis B group was significantly higher than the frequency in the control group, while the frequencies of HLA-DRB1 * 1201/1202, 1501/1502 allele were not significantly different.</p><p><b>CONCLUSION</b>HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to severe chronic hepatitis B, While HLA-DRB1 * 1201/1202, 1501/1502 have no association with severe chronic hepatitis B.</p>