The analysis of hepatitis B virus genetic characterization from immuned children and their mother / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 194-196, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-325593
ABSTRACT
<p><b>OBJECTIVE</b>In order to investigate the characterization of mother to children transmission, the sequences of HBV were analyzed to offer the information about the effect of interrupt.</p><p><b>METHODS</b>The sera of 75 mother with positive HBsAg are collected from 2003, and the ELISA was performed to determine the HBV infection of the child. The Large S sequence of HBV including preS and S gene are amplified and sequenced. The genotype was determined with the standard genotype sequence. The mutation ratios of group successfully interrupted and failed compared.</p><p><b>RESULTS</b>The sera of 4 pairs mother-children were HBsAg positive, including one twins. The virus genes are successful amplified. Four of HBV genotype is B and one is C. Gene of twins has mutation of T143M. 43 HBV of successfully interrupted group were sequenced. There are 37 of genotype B and 6 of genotype C. Three have the mutation in "a" dominant, and the percentage is 7%.</p><p><b>CONCLUSION</b>Most failed interrupted child have the same sequence with their mother, and the ratio is higher than the mother of successful group, however there have no statistical significance.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Virologia
/
Sangue
/
Anticorpos Anti-Hepatite
/
Vírus da Hepatite B
/
Vacinação
/
Vacinas contra Hepatite B
/
Transmissão Vertical de Doenças Infecciosas
/
Alergia e Imunologia
/
Genética
/
Hepatite B
Limite:
Adulto
/
Feminino
/
Humanos
/
Lactente
/
Masculino
/
Recém-Nascido
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2009
Tipo de documento:
Artigo
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