Correlation of serum chemokine RANTES level with serum biochemical indices, HBeAg and HBV DNA load in patients with chronic hepatitis B / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 188-190, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-325595
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the level of the serum chemokine RANTES and its correlation with serum biochemical indices of liver function test, HBeAg and HBV DNA load in patients with chronic hepatitis B.</p><p><b>METHODS</b>144 patients with chronic hepatitis B (observed group) and 18 normal cases (control group) were enrolled in this study. The serum level of chemokine RANTES was detected with an ABC-ELISA assay. Statistical analysis was performed on the software of SPSS13.0.</p><p><b>RESULTS</b>The serum chemokine RANTES level in the observed group (3930.12 ng/ml 2856.96) ng/ml was significantly higher than that in the control group (329.46 ng/ml +/- 152.23) ng/ml. The results from the observed group indicated the positive correlation of serum RANTES level with indices of liver function test, including ALT (r = 0.197, P = 0.018), AST(r = 0.239, P = 0.004) and TBil (r = 0.316, P = 0.001), but did not with PTA (r = - 0.078, P = 0.357). Neither difference of serum chemokine RANTES level between HBeAg-positive group and HBeAg-negative group nor that between high HBV DNA load group (> or = 10(5) copies/ml) and low HBV DNA load group (< 10(5) copies/ml) were statistically significant (P = 0.407 and 0.185, respectively).</p><p><b>CONCLUSIONS</b>Serum chemokine RANTES level in patients with chronic hepatitis B elevates significantly and is not affected by HBeAg or HBV DNA load. Its positive correlation with indices of liver function test indicates that RANTES might play an important role in the pathogenesis of chronic hepatitis B.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Virologia
/
Sangue
/
Estudos de Casos e Controles
/
Vírus da Hepatite B
/
Quimiocina CCL5
/
Carga Viral
/
Hepatite B Crônica
/
Diagnóstico
/
Antígenos E da Hepatite B
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2009
Tipo de documento:
Artigo
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