Comparative genomic hybridization analysis of nonsyndromic cleft lip with palate / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 123-125, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-325892
ABSTRACT
<p><b>OBJECTIVE</b>To identify the genetic alterations in nonsyndromic cleft lip and palate (NSCLP).</p><p><b>METHODS</b>Comparative genomic hybridization was applied to investigate the genomic imbalance (the gain or loss of genetic material) in 7 cases of NSCLP.</p><p><b>RESULTS</b>It showed that the loss of chromosome DNA copies happened in chromosome 6, 7, 10, 13, 14, 16, 20, 22 and the gain of chromosome DNA copies happened in chromosome 5, 15, 18, 19. Conclusions 13q had a high frequency (71.4%) of chromosome loss.</p><p><b>CONCLUSIONS</b>Abnormal chromosome DNA copies happen in all the patients with NSCLP. Most of the patients have chromosome DNA copies loss. It suggests that loss of inhibitory gene may be related to the NSCLP. The related inhibitory gene may locate in 13q.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Variação Genética
/
DNA
/
China
/
Fenda Labial
/
Fissura Palatina
/
Etnologia
/
Hibridização Genômica Comparativa
/
Genética
/
Genótipo
Limite:
Adolescente
/
Adulto
/
Criança
/
Criança, pré-escolar
/
Humanos
/
Lactente
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Plastic Surgery
Ano de publicação:
2008
Tipo de documento:
Artigo
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