The relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 357-360, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-326360
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma (HCC).</p><p><b>METHOD</b>The expression of FHIT and WWOX were determined by immunohistochemistry in 142 patients with HCC.</p><p><b>RESULTS</b>Absent or reduced FHIT and WWOX expression was observed in 68.3% and 77.5% of HCCs, respectively. The expression of FHIT was significantly correlated with that of WWOX (P < 0.01), and progressive loss of FHIT and WWOX expression were observed as tumor differentiation decreased and tumor grade increased (P < 0.05). Absent/reduced FHIT and WWOX expression was associated with tumor invasion and metastasis (P < 0.05). In addition, the expression of FHIT and WWOX in HCC with recrudesce were lower than that in those without recrudesce (P < 0.05).</p><p><b>CONCLUSIONS</b>Absent/reduced FHIT and WWOX expression is associated with poor prognosis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxirredutases
/
Patologia
/
Prognóstico
/
Hidrolases Anidrido Ácido
/
Carcinoma Hepatocelular
/
Perfilação da Expressão Gênica
/
Proteínas Supressoras de Tumor
/
Oxidorredutase com Domínios WW
/
Genética
/
Neoplasias Hepáticas
Tipo de estudo:
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2010
Tipo de documento:
Artigo
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