Association between paraoxonase concentration and risk of acute coronary syndrome / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 579-582, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-326466
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between paraoxonase (PON) concentration and the risk of acute coronary syndrome (ACS).</p><p><b>METHODS</b>The levels of serum PON were detected by enzyme-linked immunosorbent assay in 229 patients with confirmed ACS and 129 control subjects without CHD. Logistic regression analysis and receiver operating characteristic (ROC) curve analysis were applied to analyze the association between PON and ACS.</p><p><b>RESULTS</b>PON was significantly lower in ACS group than in control group [lgPON (5.72 ± 0.73) ng/L vs. (5.07 ± 0.57) ng/L, P < 0.05]. Logistic regression analysis showed that the level of PON was an independent risk factor of ACS (regression coefficient was -1.793 in univariate logistic regression, OR = 0.166, 95%CI 0.088 - 0.316; -0.779 in multivariate logistic regression, OR = 0.459, 95%CI 0.222 - 0.949). ROC analysis showed that the optimal diagnostic cut-off point of PON for ACS was 180 mg/L (sensitivity 83.3%, specificity 71.2%). Multiple stepwise regression analysis revealed that there was no significant correlation between lgPON and Gensini score in ACS patients.</p><p><b>CONCLUSION</b>Lower PON is linked with increased risk of ACS, but does not relate with the severity of coronary stenosis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Estudos de Casos e Controles
/
Modelos Logísticos
/
Arildialquilfosfatase
/
Síndrome Coronariana Aguda
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2012
Tipo de documento:
Artigo
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