Effects of high dose glycosides of Tripterygium wilfordii Hook. f on the fertility of young rats / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 61-63, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-326615
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effects of high dose glycosides of Tripterygium wilfordii Hook. f (GTW) on the fertility of young rats.</p><p><b>METHODS</b>Fifty female SD young rats and 50 male SD young rats were randomly divided into the blank group and the GTW group, 25 in each. GTW was given at the daily dose of 9 mg/kg. After 12 weeks of medication, the male rats were caged together with healthy adult female rats in the ratio of 11. The female rats were caged together with healthy adult male rats in the ratio of 21. The cage process lasted for two weeks, totally for three times. The pregnant rate of female rats and the survival rate of baby rats were then observed.</p><p><b>RESULTS</b>There was no significant difference in the pregnant rate or the survival rate of baby rats in the GTW group.</p><p><b>CONCLUSION</b>High dose GTW showed no obvious effects on the fertility of adult rats or the growth and development of new born rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Ratos Sprague-Dawley
/
Tripterygium
/
Fertilidade
/
Glicosídeos
Limite:
Animais
/
Gravidez
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo
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