Effect of niupo zhibao pellet on transforming growth factor-beta1 and its receptor's expression in endotoxic shock rats with lung injury / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 613-616, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-326683
ABSTRACT
<p><b>OBJECTIVE</b>To observe the influence of Niupo Zhibao pellet (NZP) on transforming growth factor-beta1 (TGF-beta1) and its receptor's expression.</p><p><b>METHODS</b>Endotoxic shock model was established by intravenous injection of lipopolysaccharide (LPS) 1.5 mg/kg and intraperitoneal injection of D-galactosamine 100 mg/kg, and intervened by NZP, TGF-beta1 and its receptor's expression in lung tissue were detected by immunohistochemical method.</p><p><b>RESULTS</b>NZP could enhance the TGF-beta1 and its receptor's expression in endotoxic shock lung tissue, and reduce the injury of lung.</p><p><b>CONCLUSION</b>The mechanism of NZP in reducing endotoxic shock lung injury is possibly related with its effect in enhancing the TGF-beta1 and its receptor's expression in lung tissue.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Síndrome do Desconforto Respiratório
/
Choque Séptico
/
Medicamentos de Ervas Chinesas
/
Lipopolissacarídeos
/
Fator de Crescimento Transformador beta
/
Ratos Sprague-Dawley
/
Receptores de Fatores de Crescimento Transformadores beta
/
Fator de Crescimento Transformador beta1
/
Galactosamina
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2004
Tipo de documento:
Artigo
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