Comparative observation on efficacy of jieyu pill and maprotiline in treating depression / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 415-417, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-326734
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical efficacy, adverse reaction and safety of Jieyu pill (JYP) in treating depression.</p><p><b>METHODS</b>The randomized controlled trial was conducted in 28 patients in the treated group and 29 patients in the control group treated with maprotiline (Map). The efficacy of treatment was evaluated before treatment and 14, 28 and 42 days after treatment, with Hamilton depression rating scale (HAMD), self-rating scale for depression (SDS), self-rating scale for anxiety (SAS) and clinical global impression (CGI), the adverse reaction was assessed by Asberg Rating Scale (ARS).</p><p><b>RESULTS</b>JYP was effective in treating depression, the markedly effective rate being 78.8%, corresponded to that of Map (82.8%, P > 0.05). After treatment, the scores assessed by HAMD, SDS and SAS were all lower than those before treatment (P < 0.01) respectively, but comparison between the two groups showed insignificant difference (P > 0.05). However, scores of ARS were significantly lower in the treated group than that in the control group, and the efficacy index of JYP was significantly higher than that of Map (P < 0.01).</p><p><b>CONCLUSION</b>JYP in treating depression shows the efficacy corresponded to that of Map and with less adverse reaction.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Escalas de Graduação Psiquiátrica
/
Medicamentos de Ervas Chinesas
/
Antidepressivos de Segunda Geração
/
Usos Terapêuticos
/
Transtorno Depressivo
/
Tratamento Farmacológico
/
Quimioterapia Combinada
/
Maprotilina
/
Fitoterapia
/
Antidepressivos
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2004
Tipo de documento:
Artigo
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