Single nucleotide polymorphisms of CTLA4 gene and their association with human cervical cancer / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 313-317, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-326939
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the association between single nucleotide polymorphisms (SNPs) of cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene and susceptibility to cervical cancer.</p><p><b>METHODS</b>One hundred patients and 100 healthy controls from Hubei province were genotyped for 20 polymorphic loci using Sequenom.</p><p><b>RESULTS</b>The frequency of rs11571316 G allele and rs5742909 T allele, which are localized in the promoter region, and rs11571319 A allele, which is downstream of the gene, were significantly higher in patients than in controls. Luciferase assay showed that, as the previously reported rs5742909 T allele, rs11571316 G allele could significantly increase the expression of the reporter gene.</p><p><b>CONCLUSION</b>SNPs in the promoter region of (CTLA4) gene might increase the susceptibility to cervical cancer by increasing (CTLA4) gene expression.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antígenos CD
/
Estudos de Casos e Controles
/
Regulação Neoplásica da Expressão Gênica
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Neoplasias do Colo do Útero
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Alelos
/
Antígeno CTLA-4
/
Genética
/
Genótipo
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2011
Tipo de documento:
Artigo
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