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The association between paternal age and schizophrenia in a Chinese Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 266-269, 2011.
Artigo em Chinês | WPRIM | ID: wpr-326950
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether advanced paternal age is related to an increased risk of schizophrenia in Chinese Han population.</p><p><b>METHODS</b>A case-control design study was performed. Three hundred and fifty-one patients with schizophrenia and 199 unrelated healthy volunteers were recruited. By using Logistic regression, paternal age was divided into five categories, and maternal age into four categories. Setting the paternal age of 26-30 years as reference, the OR, P values and 95% CI of the other paternal age categories were analyzed, respectively. The participant's sex, age and parental age at birth were used as covariants for adjusting confounding effects.</p><p><b>RESULTS</b>The OR for schizophrenia in offspring whose paternal age at birth of 31-35 years, 36-40 years, and ≥ 41 years categories were 3.834, 8.805, and 11.619 respectively. The advanced maternal age had no significant effects on the risk for schizophrenia in offspring.</p><p><b>CONCLUSION</b>The advanced paternal age was associated with elevated risk for schizophrenia in offspring among a Han Chinese population. Putative biological mechanisms may include accumulated de novo mutations and alterations in epigenetic regulations with aging in spermatogenesis.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Esquizofrenia / Idade Paterna / Povo Asiático / Genética Limite: Adolescente / Adulto / Criança / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Esquizofrenia / Idade Paterna / Povo Asiático / Genética Limite: Adolescente / Adulto / Criança / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2011 Tipo de documento: Artigo