CCR5, a new target of anti-HIV drugs / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 635-639, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-327019
ABSTRACT
CCR5, a membrane protein on cell surface, is a member of the G protein-coupled receptor superfamily and one of the major co-receptors for HIV-1 infection. The roles of CCR5 in HIV-1 infection have been elucidated since 1996. Because of the biological nature of CCR5, it has became a molecular target for the novel drugs against HIV-1. Antagonists for CCR5 could be grouped as following, chemokine derivatives, small molecule non-peptide compounds, monoclonal antibodies and peptides. The latest progress in this field is reviewed in this article.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Desenho de Fármacos
/
Infecções por HIV
/
HIV-1
/
Fármacos Anti-HIV
/
Receptores de Quimiocinas
/
Receptores CCR5
/
Antagonistas dos Receptores CCR5
/
Metabolismo
/
Anticorpos Monoclonais
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2003
Tipo de documento:
Artigo
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