Influence of obesity on pharmacokinetics and pharmacodynamics of isoflurane / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 615-618, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-327024
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of obesity on pharmacokinetics and pharmacodynamics of isoflurane.</p><p><b>METHODS</b>Twenty-six patients undergoing cholecystectomy were divided into obese group (Group A, BMI > or = 27, n = 13) and normal body weight group (Group N, BMI < or = 24, n = 13) according to body mass index (BMI). All patients were given to the same isoflurane anesthesia. Inspired and end-expired concentrations of isoflurane were monitored and uptake fraction of isoflurane were calculated.</p><p><b>RESULTS</b>Isoflurane concentrations of vaporizer in Group A [(1.8 +/- 0.3)%] were evidently higher than those in Group N [(1.5 +/- 0.1)%] at all observed points (P < 0.05 or P < 0.01). Uptake fraction of isoflurane in Group A were higher than those in Group N at observed points (P < 0.05, P < 0.01 or P < 0.001), but there were no differences in the time when isoflurane concentration was lowered to 50% and awake time between the two groups after discontinuing inhaling isoflurane.</p><p><b>CONCLUSIONS</b>Obese patients demand higher inspired concentration and uptake of isoflurane than those in normal weight patients but discharge of isoflurane was influenced by obesity within the observed period of (66 +/- 33) min.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacocinética
/
Índice de Massa Corporal
/
Colecistectomia Laparoscópica
/
Anestésicos Inalatórios
/
Relação Dose-Resposta a Droga
/
Isoflurano
/
Anestesia por Inalação
/
Metabolismo
/
Obesidade
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2003
Tipo de documento:
Artigo
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