Effect of Zuogui Pill () on monoamine neurotransmitters and sex hormones in climacteric rats with panic attack / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 190-195, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-327227
ABSTRACT
<p><b>OBJECTIVES</b>To explore the effects of Chinese medicine prescription Zuogui Pill (, ZGP) on monoamine neurotransmitters and sex hormones in climacteric rats with induced panic attacks.</p><p><b>METHODS</b>Forty-eight climacteric female rats were randomized into 6 groups with 8 rats in each group the control group, the model group, the low-, medium- and high-dose ZGP groups and the alprazolam group. Rats in the low-, medium- and high-dose ZGP groups were administered 4.725, 9.45, or 18.9 g/kg ZGP by gastric perfusion, respectively. The alprazolam group was treated by gastric perfusion with 0.036 mg/kg alprazolam. The control and model groups were treated with distilled water. The animals were pretreated once daily for 8 consecutive weeks. The behaviors of rats in the open fifield test and the elevated T-maze (ETM) were observed after induced panic attack, and the levels of brain monoamine neurotransmitters and the plasma levels of sex hormones were measured.</p><p><b>RESULTS</b>Compared with the control group, the mean ETM escape time and the levels of 5-hydroxytryptamine (5-HT) and noradrenalin (NE) of the model group were signifificantly reduced (P<0.05), Compared with the model group, the mean ETM escape time and the 5-HT and NE levels of all the ZGP groups increased signifificantly (P<0.05 or P<0.01). However, no signifificant difference was observed in the levels of sex hormones between the groups.</p><p><b>CONCLUSION</b>Pretreatment with ZGP in climacteric rats may improve the behavior of panic attack, which may be related to increased 5-HT and NE in the brain.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Hormônios Esteroides Gonadais
/
Comportamento Animal
/
Sangue
/
Climatério
/
Medicamentos de Ervas Chinesas
/
Monoaminas Biogênicas
/
Transtorno de Pânico
/
Ratos Sprague-Dawley
/
Neurotransmissores
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese journal of integrative medicine
Ano de publicação:
2017
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS