Expression and significance of alpha5beta1 integrin in abnormal scars / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 271-273, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-327257
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of alpha5beta1 integrin in the abnormal scars and its role and significance in the formation and development of abnormal scars.</p><p><b>METHODS</b>The expression of alpha5beta1 integrin was observed in hypertrophic scar (15 samples), keloid (15 samples) and normal skin (10 samples) with SP immunohistochemical method and colloidal gold immuno-electron microscopic technique. The data were semi-quantitatively analyzed.</p><p><b>RESULTS</b>The expression levels of alpha5beta1 integrin in the fibroblasts of keloids and hypertrophic scars were higher than normal skin; the expression of alpha5beta1 integrin in the fibroblasts of keloids was higher than hypertrophic scars (P < 0.01).</p><p><b>CONCLUSION</b>The alpha5beta1 integrin appears to have close relation to the formation and development of abnormal scars. To find a way to decrease the expression level of alpha5beta1 integrin in fibroblasts may be a new approach to inhibit scar hypertrophy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Pele
/
Imuno-Histoquímica
/
Química
/
Microscopia Imunoeletrônica
/
Cicatriz
/
Integrina alfa5beta1
/
Queloide
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Plastic Surgery
Ano de publicação:
2004
Tipo de documento:
Artigo
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