Advances in the research of modulation of dermal collagen fibrin assembly by decorin / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 157-159, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-327419
ABSTRACT
Formation of dermal collagen fiber is a complicated and sequential process with the progressive assembly of collagen. Collagen monomers form stepped and orderly protofibrils through longitudinal displacement. Subsequently, protofibrils or protofibrils and collagen are bonded by covalent bonds to form orderly lamellar structure of collagen fibers. Then collagen fibers are tightly wound into coarse collagen fiber bundles by covalent crosslinking. Decorin is a multifunctional small leucine-rich proteoglycan. It can prevent the aggregation of protofibrils by binding to the specific site of collagen with its core protein, and adjusting the spacing between the protofibrils with its glycosaminoglycan chain. Thus, by effecting the formation of collagen fibers with regulation of collagen assembly, decorin may help prevent scar formation and even promote regeneration.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Proteoglicanas
/
Fibrina
/
Proteínas da Matriz Extracelular
/
Colágeno
/
Microfibrilas
/
Colágenos Fibrilares
/
Matriz Extracelular
/
Decorina
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Burns
Ano de publicação:
2015
Tipo de documento:
Artigo
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