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Effects of three Chinese herbal antidotes (Herba artemisiae annuae, Herba hedyotis diffusae and Rhizoma cimicifugae) and their different combinations on regulated on activation normal T cell expressed and secreated expression in MRL/lpr mice / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 1306-1309, 2010.
Artigo em Chinês | WPRIM | ID: wpr-327446
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effects of three Chinese herbal antidotes, i.e. Herba Artemisiae annuae (A), Herba Hedyotis diffusae (H) and Rhizoma Cimicifugae (C), all were ingredients of Jiedu Quyu Ziyin Recipe, for adjusting the regulated on activation normal T cell expressed and secreated (RANTES), gene expression in serum and renal tissue of MRL/lpr mice.</p><p><b>METHODS</b>Fifty-four MRL/lpr mice were randomized into 9 groups, with 6 in each, and intragastrically infused with A, H, C, A+H, H+C, A+C, A+H+C (all in dosage-form of decoction), prednisone suspension and physiological saline, respectively for 12 weeks. RANTES expression in serum and renal tissue of animals were detected with ELISA and RT-PCR at the end of the study.</p><p><b>RESULTS</b>Levels of RANTES expression was significantly reduced in the prednisone treated group after treatment. Excepting no significant change being observed in the groups treated with A and C, the changes in the other groups were all milder than those in the group treated with A+H+C.</p><p><b>CONCLUSION</b>Chinese herbal antidotes A, H and C in combination can significantly inhibit the RANTES expression in serum and renal tissue of MRL/lpr mice.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Sangue / Medicamentos de Ervas Chinesas / Linfócitos T / Química / Quimiocina CCL5 / Camundongos Endogâmicos MRL lpr / Artemisia annua / Cimicifuga / Hedyotis Limite: Animais Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Sangue / Medicamentos de Ervas Chinesas / Linfócitos T / Química / Quimiocina CCL5 / Camundongos Endogâmicos MRL lpr / Artemisia annua / Cimicifuga / Hedyotis Limite: Animais Idioma: Chinês Revista: Chinese Journal of Integrated Traditional and Western Medicine Ano de publicação: 2010 Tipo de documento: Artigo