Meta-analysis on the prognostic value of pregnancy-associated plasma protein-A in acute coronary syndrome / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 279-284, 2013.
Article
em Zh
| WPRIM
| ID: wpr-327626
Biblioteca responsável:
WPRO
ABSTRACT
Objective To evaluate the overall prognostic effects of pregnancy-associated plasma protein-A (PAPP-A) in acute coronary syndrome (ACS)through a meta-analysis.Methods Literature was retrieved by formal searching of electronic databases (PubMed,EMBASE,OVID,Web of Knowledge,and the Cochrane Library) and by hand searching of reference lists of related articles.Random effects meta-analysis and relative risk were used to estimate the association between PAPP-A levels and adverse cardiovascular outcomes after ACS as well as preplanned subgroup analyses were conducted to identify the risk-subgroup interactions that could explain the between differences.Results A total of fourteen clinical trials were included in this Meta-analysis which involving 9413 patients.Pooled RR and their 95% confidence intervals (CIs) for all eligible studies was 1.97 (1.49-2.60),which indicated a prognostic value of PAPP-A in patients with ACS.Differences in study design,measurement of association and duration of follow-up were responsible for the differences in results across the studies.Conclusion Our results suggested that a higher early blood PAPP-A could moderately increase the long-term risk of adverse cardiovascular outcomes and might serve as a valuable prognostic predictor in patients with ACS.
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Índice:
WPRIM
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
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Systematic_reviews
Idioma:
Zh
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2013
Tipo de documento:
Article