Study on the risk factors of tuberculosis in four cities and provinces in China / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the influencing factors on tuberculosis (TB) in four provinces in the eastern and central parts of China.</p><p><b>METHODS</b>From Nov. 2009 to Feb. 2011, three population-based field surveys were conducted among the resident population in several townships/streets in Guangdong, Hunan and Jiangsu provinces and Shanghai municipality to collect TB-related information. 474 sputum smear positive TB patients and 1896 controls were randomly selected from the population under study and each case was matched by province, age and sex using a frequency matching method. Single-variable and multiple non-conditional logistic regression modeling were applied for data analysis, and odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were estimated.</p><p><b>RESULTS</b>Data from Single-variable analysis showed that TB history, history of exposure to TB, DM history, immigrant population and per-capita living space were risk factors for TB, and high level of education was protective factors.</p><p><b>RESULTS</b>from multiple logistic regression showed that the risk factors of TB would include the following items history of having had TB (OR = 52.356, 95%CI 18.956 - 144.607), living space over 50 m(2)per-capita (OR = 8.742, 95%CI 1.107 - 69.064), history of exposure to TB (OR = 6.083, 95%CI 2.336 - 15.839) and being immigrants (OR = 3.306, 95%CI 1.907 - 5.734), while having had high degree of education as the protective factor of TB (OR = 0.284, 95%CI 0.110 - 0.733).</p><p><b>CONCLUSION</b>Control programs targeting those ever having TB patients and contacts to TB patients as well as immigrants should be strengthened.</p>