Research on expression of human papillomavirus type 16 and telomerase in oral lesions / 中华口腔医学杂志
Chinese Journal of Stomatology
; (12): 119-121, 2001.
Article
em Zh
| WPRIM
| ID: wpr-327927
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To define a correlation between human papillomavirus (HPV) type 16 and telomerase activity during the carcinogenesis of oral mucosa.</p><p><b>METHODS</b>HPV16 DNA and human telomerase reverse transcriptase (hTRT) mRNA were detected in 82 cases of paraffin embedded tissues including 7 cases of normal oral mucosa, 7 cases of hyperplasia lesions, 30 cases of oral dysplasia lesions and 38 cases of oral squamous cell carcinomas (OSCCs) by PCR and in situ hybridization (ISH) respectively.</p><p><b>RESULTS</b>HPV16DNA was positive in 14.3% (1/7) of normal oral mucosa, 42.9% (3/7) of hyperplasia lesions, 66.6% (20/30) of dysplasia lesions and 92.1% (35/38) of OSCCs. hTRTmRNA was detectable in 30.0% (9/30) of oral dysplasia lesions and 81.6% (31/35) of OSCCs while normal oral mucosa and hyperplasia lesions were negative. Expression of HPV16DNA and hTRTmRNA were co-ordinate in 67.0% (55/82) cases.</p><p><b>CONCLUSIONS</b>HPV16 infection may play an important role in carcinogenesis of oral mucosa by activation of telomerase.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Papillomaviridae
/
Patologia
/
Virologia
/
DNA Viral
/
RNA Mensageiro
/
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Telomerase
/
Proteínas de Ligação a DNA
/
Genética
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Stomatology
Ano de publicação:
2001
Tipo de documento:
Article