Biodistribution study of 131I-gM-CSF in SCID mice bearing human leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 678-681, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-328400
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the biodistribution of 131I-GM-CSF in SCID mice bearing human AML in vivo.</p><p><b>METHODS</b>The xenograft model of human leukemia was established in SCID mice. In the leukemia mice, the biodistribution of 131I-GM-CSF produced by chlo amine-T method was studied.</p><p><b>RESULTS</b>(1)The inoculated HL-60 cells could grow in SCID mice, which developed leukemia after 4 weeks. (2) 131 I-GM-CSF was concentrated in spleen, bone marrow and tumor tissue of the mice. In spleen and bone marrow, 131 I-GM-CSF was uptaken to peak in 30 minutes after injection, the up taking rate was (442. 9+/-86. 4) % ID/g and (4283. 8+/-252. 8)% ID/g, respectively, and maintained on higher level in 24 hours. The injection of 131I resulted in an even distribution in the whole body.</p><p><b>CONCLUSIONS</b>131 I-GM-CSF is able to concentrate electively in spleen, bone marrow and organs infiltrated by leukemia cells. The biodistribution of 131I-GM-CSF in the leukemia mice is tissue specific.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacocinética
/
Leucemia Mieloide Aguda
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
/
Camundongos SCID
/
Células HL-60
/
Ensaios Antitumorais Modelo de Xenoenxerto
/
Citometria de Fluxo
/
Radioisótopos do Iodo
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2006
Tipo de documento:
Artigo
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