Study on serum erythropoietin levels in patients with hematologic malignancies / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 543-545, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-328421
ABSTRACT
<p><b>OBJECTIVE</b>To study whether hematologic malignancy patients with anemia have a lower erythropoietin (EPO) response.</p><p><b>METHODS</b>Serum EPO levels were detected by ELISA in patients with hematologic malignancies and with iron deficiency anemia (IDA). Eighty patients with hematologic malignancies, including 13 multiple myeloma (MM), 7 chronic lymphocytic leukemia (CLL) and 60 non-Hodgkin's lymphoma (NHL) were studied. Thirty of them had anemia(21 NHL,6 MM and 3 CLL). Twenty patients with IDA were studied as the control.</p><p><b>RESULTS</b>Hematologic malignancy patients with anemia had higher EPO levels [(97.8 +/- 183.9) IU/L] than those with normal Hb values [(27.8 +/- 85.4) IU/L; P <0.01]. In patients with IDA, serum EPO response was inversely correlated with Hb level (r= -0.5, P <0.05) , but no such inverse correlation was found in the hematologic malignancy patients with anemia (r = -0.14). After corrected for Hb level, the serum EPO levels were significantly lower in anemic patients with hematologic malignancies than in IDA patients (P = 0.032) , indicating a decreased EPO response in the former group.</p><p><b>CONCLUSION</b>Anemia associated with hematologic malignancy might result from an inappropriately low EPO response. EPO treatment for these patients may be beneficial.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Hemoglobinas
/
Ensaio de Imunoadsorção Enzimática
/
Estudos Prospectivos
/
Eritropoetina
/
Anemia Ferropriva
/
Neoplasias Hematológicas
/
Metabolismo
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2006
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS