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Detecting microdeletions of the Y chromosome in patients with high follicle-stimulating hormone azoospermia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 485-487, 2004.
Artigo em Chinês | WPRIM | ID: wpr-328843
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between the patients' high follicle-stimulating hormone (FSH) azoospermia and microdeletions in Y chromosome.</p><p><b>METHODS</b>Eleven sequence tagged sites (STSs) in Yq were detected by PCR in 16 male patients' high FSH azoospermia.</p><p><b>RESULTS</b>Microdeletions were observed in 6 of 16 male patients and the deletion rate was 37.5%(6/16). Five types of microdeletions were detected AZFc(SY152), AZFc (SY152+SY254)+AZFd (SY153), AZFc (SY152+SY254+SY255)+AZFd (SY153), AZFc (SY152+SY158+SY255)+AZFd (SY153),and AZFb (SY130)+AZFc (SY158+SY254+SY255)+AZFd (SY153) respectively.</p><p><b>CONCLUSION</b>Microdeletion of Y chromosome was one of the important reasons of the patients' high FSH azoospermia. Before the application of assisted-reproductive technology (ART) to the patients, it is necessary to detect the microdeletions, especially AZFc and AZFd.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Reação em Cadeia da Polimerase / Sitios de Sequências Rotuladas / Deleção Cromossômica / Cromossomos Humanos Y / Azoospermia / Hormônio Foliculoestimulante / Genética / Infertilidade Masculina / Metabolismo Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2004 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Reação em Cadeia da Polimerase / Sitios de Sequências Rotuladas / Deleção Cromossômica / Cromossomos Humanos Y / Azoospermia / Hormônio Foliculoestimulante / Genética / Infertilidade Masculina / Metabolismo Limite: Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Medical Genetics Ano de publicação: 2004 Tipo de documento: Artigo