Molecular pharmacogenetic studies of drug responses to obsessive-compulsive disorder and six functional genes / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 479-481, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-328845
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the associations between the drug responses to obsessive -pulsive disorder (OCD) and six functional genes related with serotonin and dopamine.</p><p><b>METHODS</b>One hundred and thirteen OCD nuclear families were collected. The OCD patients were treated with serotonin reuptake inhibitors (SRIs) for 8 weeks and the drug responses were assessed using the Yale-Brown obsessive-compulsive scale (Y-BOCS). The patients were divided into drug responders group and non-responders group according to the reducing rate of Y-BOCS score. The genotypes of six genes were determined with the Amp-FLP and Amp-RFLP techniques and analyzed by transmission disequilibrium test (TDT). The six genes are serotonin 2A receptor (5-HT2A), serotonin transporter (5-HTT), dopamine D2 receptor ( DRD2), dopamine D4 receptor (DRD4), catechol-O- methyltransferase (COMT) and monoamine oxidase A (MAOA).</p><p><b>RESULTS</b>No association was found between the six genes and different drug responses groups. However, there was significant difference between the drug responders and non-responders in homozygosity at the 5-HT2A -1438G/A locus (chi(2)=4.69, P=0.03).</p><p><b>CONCLUSION</b>The results suggested that the 5-HT2A may play some roles in the effects of drug treatment on OCD.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacogenética
/
Catecol O-Metiltransferase
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Resultado do Tratamento
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Inibidores Seletivos de Recaptação de Serotonina
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Receptores de Dopamina D2
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Receptor 5-HT2A de Serotonina
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Usos Terapêuticos
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Tratamento Farmacológico
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Proteínas da Membrana Plasmática de Transporte de Serotonina
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Receptores de Dopamina D4
Limite:
Adolescente
/
Adulto
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Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2004
Tipo de documento:
Artigo
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