The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 339-341, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-328882
ABSTRACT
<p><b>OBJECTIVE</b>To explore the association of the microsatellite polymorphisms in the promoter region of alpha-synuclein gene with the late-onset sporadic Parkinson's disease (PD) susceptibility.</p><p><b>METHODS</b>The microsatellite polymorphism of alpha-synuclein gene was analyzed with amplified fragment length polymorphism (Amp-FLP) and semiautomatic fluorescent labeled genotyping technique. Association analysis was performed in 135 unrelated late-onset sporadic PD patients and 170 age-matched healthy controls.</p><p><b>RESULTS</b>The distribution of the alleles of the dinucleotide repeats variants of alpha-synuclein gene promoter region in PD cases was significantly different from that in the healthy controls. The most frequent allele in PD patients was allele 269 bp, but in controls it was the 271 bp allele. Alleles of <or=267 bp showed positive correlation with PD risk (OR=5.228, 95%CI 1.248-27.202, chi-square=6.416, P=0.011), while the 273 bp allele was negatively correlated to PD (OR=0.638, 95%CI 0.440-0.926, chi-square=5.644, P=0.018). Furthermore, no difference of genotype polymorphism distribution was shown between the two groups (chi-square=16.368, df=12, P=0.175). But the genotypes containing <or=267 bp allele may increase the susceptibility to PD (OR=4.594, 95%CI 0.94-22.49, chi-square=4.224, P=0.04). Heterozygosity was 40% in PD patients, and 50% in controls.</p><p><b>CONCLUSION</b>alpha-synuclein microsatellite polymorphism might be a genetic susceptibility factor for late-onset sporadic PD.</p>
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Polimorfismo Genético
/
Razão de Chances
/
China
/
Epidemiologia
/
Idade de Início
/
Repetições de Microssatélites
/
Predisposição Genética para Doença
/
Alfa-Sinucleína
/
Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Tipo de estudo:
Estudo de etiologia
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2004
Tipo de documento:
Artigo
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