Alleles of HLA class II DRB1 of patients with essential hypertension in Yunnan Hans / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 286-287, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-328895
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the alleles of human leukocyte antigens (HLA)-DRB1 and essential hypertension (EH) in the Hans living in Yunnan of China.</p><p><b>METHODS</b>The alleles of HLA-DRB1 were typed by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in samples from 83 patients with essential hypertension and 91 healthy controls. All of the subjects, their grandparents and grand-grandparents are Hans living in Yunnan of China.</p><p><b>RESULTS</b>The frequency of DRB1*1501/2 in the EH patients (0.219) was significantly higher than that in the controls(0.060), chi quare=18.331, P<0.01. Relative risk (RR) was 4.46, and etiologic factor (EF) was 0.34. The frequency of DRB1*0901 significantly decreased in the group of patients with EH in comparison to the controls (0.081 versus 0.192) chi-square=8.704 P<0.05. RR was 0.41 and prevention factor(PF) was 0.19.</p><p><b>CONCLUSION</b>HLA-DRB1*1501/2 is associated with the susceptibility to essential hypertension in the Yunnan Hans of China. DRB1*0901 may protect one from the disease.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antígenos HLA-DR
/
China
/
Alelos
/
Etnologia
/
Cadeias HLA-DRB1
/
Genética
/
Hipertensão
Tipo de estudo:
Estudo de etiologia
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2004
Tipo de documento:
Artigo
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