Successful Desensitization of Oxcarbazepine: First Case in Pediatric Patient / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 262-265, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-32906
ABSTRACT
Aromatic antiepileptic drugs (AEDs), such as diphenylhydantoin, phenobarbital, or carbamazepine (CBZ), are frequently associated with hypersensitivity reactions. This may restrict treatment options considerably due to cross reactivity with other aromatic AEDs. Desensitization can be very helpful for patients who show cross sensitivity with other AEDs. We report a case an 8-year-old patient who had cross sensitivity to oxcarbazepine (OXC) and CBZ and successfully managed by desensitization to OXC. The patient presented with intractable frontal lobe epilepsy. He had become seizure free with OXC; however OXC had to be discontinued due to whole body rash. CBZ also caused a hypersensitivity reaction. Therefore, OXC desensitization was attempted; he then had very subtle seizures during sleep with a frequency of 5 to 6 episodes per month on the 18th month of desensitization. Desensitization can be considered in a patient with limited treatment options due to hypersensitivity to aromatic AEDs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenobarbital
/
Fenitoína
/
Convulsões
/
Carbamazepina
/
Epilepsia do Lobo Frontal
/
Exantema
/
Hipersensibilidade
/
Anticonvulsivantes
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Journal of the Korean Child Neurology Society
Ano de publicação:
2011
Tipo de documento:
Artigo
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