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Telomerase activity in condyloma acuminatum tissue with different HPV types / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 171-173, 2002.
Artigo em Inglês | WPRIM | ID: wpr-329150
ABSTRACT
The telomerase activity in condyloma acuminatum (CA) tissue with human papillomavirus (HPV) types of 6/11 and 16/18 was detected to investigate the function of telomerase in the occurrence, development and carcinogenesis of genital CA. Forty-two biopsies from patients with genital CA and 30 control tissue samples were tested for telomerase activity, HPV presence and types. The telomerase activity was determined by modified telomerase repeat amplification protocol (TRAP) assay and HPV typing by polymerase chain reaction (PCR) with typing-specific primers. Results showed that HPV-DNA was negative and the expression rate of telomerase was 16.7% in all normal skin samples. All CA samples were positive for HPV (6/11 type was found in 32 cases, 16/18 in 3 and mixed type in 7). Telomerase activity was detectable in all CA patients. The telomerase activity in CA of 16/18 type was apparently higher than in CA of 6/11 type. It was concluded that the hyperplasia in CA might be increased as a result of HPV infection, suggesting that the activation of telomerase by HPV, especially by 16/18 type may play a role in the etiology and carcinogenesis of genital CA.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Papillomaviridae / Infecções Tumorais por Vírus / Virologia / Condiloma Acuminado / Classificação / Telomerase / Infecções por Papillomavirus / Doenças dos Genitais Femininos / Doenças dos Genitais Masculinos / Metabolismo Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Ano de publicação: 2002 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Papillomaviridae / Infecções Tumorais por Vírus / Virologia / Condiloma Acuminado / Classificação / Telomerase / Infecções por Papillomavirus / Doenças dos Genitais Femininos / Doenças dos Genitais Masculinos / Metabolismo Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Journal of Huazhong University of Science and Technology (Medical Sciences) Ano de publicação: 2002 Tipo de documento: Artigo