Genetic polymorphisms of short tandem repeats loci F13A01, FESFPS, vWA from Han population in Guizhou / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To understand the allele structure and genetic polymorphism at F13A01, FESFPS and vWA short tandem repeats (STRs) loci for Han population in Guizhou province of China, and to construct a preliminary database.</p><p><b>METHODS</b>One hundred sixty unrelated individuals in Han population from Guizhou were analyzed by multiplex polymerase chain reaction. The resultant allele frequencies were compared with those of other population or race database.</p><p><b>RESULTS</b>The genotype distributions of F13A01, FESFPS and vWA were in accordance with Hardy-Weinberg equilibrium. The combined discrimination power and polymorphism information content were 0.9984 and 0.9700 respectively.</p><p><b>CONCLUSION</b>All of the three loci in this study provide useful markers for forensic paternity test and for genetic purposes.</p>