Study on the genic polymorphism of HLA-DRB1 in a population in the north of China / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 325-327, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-329470
ABSTRACT
<p><b>OBJECTIVE</b>To investigate at the DNA level the polymorphism of HLA-DRB1 gene in Han population in Beijing of China.</p><p><b>METHODS</b>This study was conducted in the Hans in Beijing. A total of 2810 normal and unrelated neonates were analyzed and subjected to HLA-DRB1 low resolution typing, and from among them 217 neonates were randomly selected for DRB1 high resolution typing by polymerase chain reaction-sequence specific primers technique.</p><p><b>RESULTS</b>Fourteen HLA-DRB1 specificity and 39 alleles were found with HLA-DRB1 *09012, *1501, *07011, *08032 as the most common genes. Their gene frequencies and allelic distributions were compared to those observed in other ethnic populations.</p><p><b>CONCLUSION</b>The results showed the characteristic of HLA-DRB1 distribution, and provided more comprehensive and accurate gene data that may serve as normal reference values for the population in Beijing, China.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Antígenos HLA-DR
/
China
/
Reação em Cadeia da Polimerase
/
Povo Asiático
/
Cadeias HLA-DRB1
/
Frequência do Gene
/
Genética
/
Genética Populacional
Limite:
Feminino
/
Humanos
/
Masculino
/
Recém-Nascido
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2003
Tipo de documento:
Artigo
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