Comparative study on schizontocidal activity of recrystallized or crude daphnetin against malaria parasites / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 397-401, 2004.
Artigo
em Inglês
| WPRIM
| ID: wpr-329621
ABSTRACT
<p><b>OBJECTIVE</b>To compare the schizontocidal activity of recrystallized or crude daphnetin against malaria parasites in vivo.</p><p><b>METHODS</b>Schizontocidal activity of recrystallized or crude daphnetin at various dosages was assessed in mice infected with Plasmodium berghei ANKA using a "4-day suppress assay".</p><p><b>RESULTS</b>The comparison of the reduction rate of parasitemia caused by either recrystallized or crude dephnetin showed that ED(50) of crude daphnetin was 18.36 mg/kg, with 95% confidence limit of 5.96-56.54 mg/kg while ED50 of recrystallized daphnetin was 11.46 mg/kg, with 95% confidence limit of 8.63-15.22 mg/kg.</p><p><b>CONCLUSION</b>The results indicate that the efficacy of recrystallized daphnetin is 37.6% higher than that of crude daphnetin.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Parasitologia
/
Farmacologia
/
Plasmodium berghei
/
Umbeliferonas
/
Cromatografia Líquida de Alta Pressão
/
Testes de Sensibilidade Parasitária
/
Relação Dose-Resposta a Droga
/
Tratamento Farmacológico
/
Malária
/
Antimaláricos
Limite:
Animais
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2004
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS