Therapeutic effect of inulin on enteric hyperoxaluria in rats / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 313-316, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-329827
ABSTRACT
<p><b>OBJECTIVE</b>To observe the therapeutic effect of inulin on enteric hyperoxaluria in rats.</p><p><b>METHODS</b>In experimental A, 24 healthy male Sprague-Dawley rats received an oxalate-free diet on day 1, a high-oxalate diet (oxalate, 74.82 mg/100 g feed stuffs) on days 2 and 3, and plus 2 g inulin to each rat on day 3. The 24-hour urinary volume, concentrations of urinary oxalate and urine creatinine were measured, and 24-hour urinary oxalate excretion was calculated. In experimental B, 24 healthy male Sprague-Dawley rats were equally randomized into control group and inulin group, Each rat received a high oxalate diet (oxalate, 74.82 mg/100 g feedstuffs), and plus 2 g inulin in inulin group. The 24-hour urinary oxalate excretion was calculated in both two groups.</p><p><b>RESULTS</b>In experimental A, the 24-hour urinary oxalate excretion varied with time (F=11.481, P=0.035). The 24-hour urinary oxalate excretion significantly increased on day 2 compared with that on day 1 (P=0.026) and day 3 (P=0.037); it significantly increased on day 3 compared with day 1 (P=0.004). In experimental B, the 24-hour urinary oxalate excretion significantly decreased in inulin group compared with the control (P=0.011).</p><p><b>CONCLUSION</b>Inulin may have potential therapeutic effect on enteric hyperoxaluria in rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hiperoxalúria
/
Resultado do Tratamento
/
Ratos Sprague-Dawley
/
Usos Terapêuticos
/
Modelos Animais de Doenças
/
Tratamento Farmacológico
/
Inulina
Limite:
Animais
Idioma:
Inglês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2014
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS