The effects of pH0 on electrophysiological properties of VSMCs in brain artery of spontaneously hypertensive rats / 中国应用生理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effects of pH0 on the electrophysiological properties of vascular smooth muscle cells (VSMCs) in brain artery of spontaneously hypertension rats (SHR).</p><p><b>METHODS</b>We studied the effects and the ion mechanism of pH0 on whole-cell membrane current of VSMCs in brain artery of 200 - 250 g SHR by whole-cell patch clamp recordings.</p><p><b>RESULTS</b>1. Acidic pH0 could inhibit the outward current of VSMCs of brain artery in SHR in a voltage-dependent manner. It induced a more pronounced inhibition of the outward current from 0 to + 60mV; 2. In the presence of 1 mmol/L TEA, the inhibition of acidic pH0 on the outward current of VSMCs of brain artery was inhibited.</p><p><b>CONCLUSION</b>The changes of outward current of VSMCs of brain artery in SHR induced by pH0 may be connected with BKCa channel.</p>